Description

3-Aminomethyl-2-Fmoc-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a protected amino acid derivative and a key building block in modern organic synthesis. Its primary value lies in its role as a sophisticated intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics. This high-purity compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates targeting neurological disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in Fmoc-strategy solid-phase peptide synthesis (SPPS) to incorporate the 1,2,3,4-tetrahydroisoquinoline scaffold into peptide chains.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing combinatorial libraries and exploring structure-activity relationships (SAR) in drug discovery.
• Bioconjugation: Can be utilized for the site-specific modification of peptides and proteins due to its reactive amino group.
• Chemical Biology Probes: Employed in the development of labeled peptides and probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	3-Aminomethyl-2-Fmoc-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	1187932-19-9
Molecular Formula	C26H25N2O2·HCl
Molecular Weight	424.95 g/mol
Synonyms	Fmoc-ATIQ-OH·HCl; 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-methanamine hydrochloride; 3-(Aminomethyl)-2-[(9H-fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride; Fmoc-3-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid hydrochloride; Fmoc-3-Aminomethyl-Tic-OH·HCl; (2S,3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride (stereoisomer)
EINECS	Contact for details

Quality Control

Our 3-Aminomethyl-2-Fmoc-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.