Description

(R)-4-(3-Hydroxy-Pyrrolidin-1-Ylmethyl)-Benzoic Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Chiral Building Block: Used in asymmetric synthesis to introduce the (R)-configured 3-hydroxypyrrolidine moiety into more complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the synthesis of compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the optimization and commercial-scale production of candidate drugs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(R)-4-(3-Hydroxy-Pyrrolidin-1-Ylmethyl)-Benzoic Acid Hydrochloride
CAS No.	1187931-68-5
Molecular Formula	C13H18ClNO3
Molecular Weight	271.74 g/mol
Synonyms	(R)-4-((3-Hydroxypyrrolidin-1-yl)methyl)benzoic acid hydrochloride; Benzoic acid, 4-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-, hydrochloride; (R)-4-((3-Hydroxy-pyrrolidin-1-yl)-methyl)-benzoic acid HCl; (R)-4-(3-Hydroxy-1-pyrrolidinylmethyl)benzoic acid hydrochloride; (R)-HPMB HCl
EINECS	Contact for details

Quality Control

Our (R)-4-(3-Hydroxy-Pyrrolidin-1-Ylmethyl)-Benzoic Acid Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material compliant with current Good Manufacturing Practice (cGMP) standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.