Description

2-Amino-1-(3,5-Difluoro-Phenyl)-Ethanone Hydrochloride is a high-purity, synthetically valuable organic intermediate. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals due to its reactive amine and ketone functional groups within a difluorinated aromatic framework. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorophenyl moiety can enhance biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile precursor for heterocyclic chemistry, enabling the creation of novel scaffolds for material science and catalyst development.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up synthesis of specific APIs where this precise chemical structure is required in the final synthetic route.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands for metal catalysis or as a component in organocatalysts.

Basic Information

Product Name	2-Amino-1-(3,5-Difluoro-Phenyl)-Ethanone Hydrochloride
CAS No.	1187931-06-1
Molecular Formula	C8H8F2NO•HCl
Molecular Weight	209.61 g/mol (Free base: 173.15 g/mol)
Synonyms	1-(3,5-Difluorophenyl)-2-aminoethanone hydrochloride; 2-Amino-1-(3,5-difluorophenyl)ethan-1-one hydrochloride; 3',5'-Difluoro-2-aminoacetophenone hydrochloride; α-Amino-3,5-difluoroacetophenone hydrochloride; 2-Amino-3',5'-difluoroacetophenone HCl; 1-(3,5-Difluorophenyl)-2-amino-1-ethanone hydrochloride; 2-Amino-1-(3,5-difluorophenyl)ethanone HCl
EINECS	Contact for details

Quality Control

Our 2-Amino-1-(3,5-Difluorophenyl)-Ethanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.