Description

(R)-1-(4-Chlorophenyl)-2,2,2-Trifluoroethanamine Dihydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring enantiomerically pure molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore the biological activity of the (R)-enantiomer.
• Process Chemistry Development: Serves as a starting material or intermediate in the development of scalable, asymmetric synthetic routes for API manufacturing.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in chiral HPLC or SFC analysis.
• Ligand and Catalyst Precursor: Potential use in the preparation of chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Item	Details
Product Name	(R)-1-(4-Chlorophenyl)-2,2,2-Trifluoroethanamine Dihydrochloride
CAS No.	1187931-01-6
Molecular Formula	C8H8ClF3N · 2HCl
Molecular Weight	286.96 g/mol (Free base: 209.61 g/mol)
Synonyms	(R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanamine dihydrochloride; (R)-4-Chloro-α-(trifluoromethyl)benzylamine dihydrochloride; (R)-1-(4-Chlorophenyl)-2,2,2-trifluoroethylamine dihydrochloride; (R)-α-(4-Chlorophenyl)-2,2,2-trifluoroethylamine hydrochloride (1:2); (R)-CFT Dihydrochloride; (R)-Para-Chloro-α-trifluoromethylphenethylamine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Chlorophenyl)-2,2,2-Trifluoroethanamine Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.