Description

n-Trityl Histamine Oxalate is a protected derivative of the biogenic amine histamine, where the trityl group serves as a protective moiety for the imidazole nitrogen. This compound is of significant value in advanced organic synthesis and medicinal chemistry research, particularly for the controlled preparation of histamine analogs and related pharmacologically active molecules. It is primarily utilized by researchers and process development chemists in the pharmaceutical, biotechnology, and fine chemical sectors for developing new therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel histamine receptor ligands and other bioactive compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize drug candidates targeting histaminergic pathways.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled histamine derivatives used in biochemical assays and diagnostic applications.
• Process Chemistry: Employed in scalable synthetic routes where the trityl protecting group provides selectivity and stability during multi-step reactions.
• Academic Research: Utilized in universities and research institutes for studying histamine metabolism, signaling, and the development of research tools.

Basic Information

Product Name	n-Trityl Histamine Oxalate
CAS No.	1187929-12-9
Molecular Formula	C25H24N4O4 • C2H2O4
Molecular Weight	534.56 g/mol
Synonyms	N-Tritylhistamine Oxalate; Histamine, N-trityl-, oxalate (1:1); 2-(1H-Imidazol-4-yl)ethanamine, N-(triphenylmethyl)-, ethanedioate (1:1); N-Trityl-1H-imidazole-4-ethanamine Oxalate; Triphenylmethylhistamine Oxalate; N-(Triphenylmethyl)histamine Oxalate; 4-(2-Aminoethyl)-1-tritylimidazole Oxalate
EINECS	Contact for details

Quality Control

Our n-Trityl Histamine Oxalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.