Description

(3R)-4-Cbz-3,4-Morpholinedicarboxylic Acid CAS NO 1187928-95-5 is a high-purity, chiral morpholine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a sophisticated intermediate for constructing complex pharmaceutical molecules, particularly in the development of targeted therapeutics. This compound is essential for research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), proteolysis-targeting chimeras (PROTACs), and other bioactive compounds requiring precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• PROTAC Linker Chemistry: Utilized in the design and synthesis of Proteolysis-Targeting Chimeras due to its rigid morpholine scaffold and functional handles.
• Peptidomimetics & Constrained Peptides: Incorporated to introduce conformational restraint and improve metabolic stability in peptide-based drug design.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Chemical Biology Probes: Serves as a component in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Item	Detail
Product Name	(3R)-4-Cbz-3,4-Morpholinedicarboxylic Acid
CAS No.	1187928-95-5
Molecular Formula	C15H17NO6
Molecular Weight	307.30 g/mol
Synonyms	(3R)-4-[(Benzyloxy)carbonyl]-3,4-morpholinedicarboxylic acid; (3R)-4-Carboxybenzyl 3,4-morpholinedicarboxylate; (R)-4-Cbz-3,4-morpholinedicarboxylic acid; 4-[(Benzyloxy)carbonyl]-3,4-morpholinedicarboxylic acid, (3R)-; (3R)-4-(Benzyloxycarbonyl)-3,4-morpholinedicarboxylic acid; Morpholine-3,4-dicarboxylic acid, 4-[(phenylmethoxy)carbonyl]-, (3R)-; Z-3,4-Morpholinedicarboxylic Acid, (3R)-
EINECS	Contact for details

Quality Control

Our (3R)-4-Cbz-3,4-Morpholinedicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.