Description

(R)-Amino-(Tetrahydro-Pyran-4-Yl)-Acetic Acid Methyl Ester Oxalate is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its stereochemically defined structure, which is critical for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in advanced organic synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Used as a precursor for constructing complex molecules with defined stereochemistry in catalytic and stoichiometric asymmetric transformations.
• Peptidomimetics & Bioactive Molecule Development: Serves as a constrained amino acid analog for designing peptide-like compounds with enhanced metabolic stability and receptor selectivity.
• Agrochemical Research: Employed in the synthesis of chiral active ingredients for crop protection products, where stereochemistry can influence efficacy and environmental profile.
• Ligand & Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in enantioselective reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(R)-Amino-(Tetrahydro-Pyran-4-Yl)-Acetic Acid Methyl Ester Oxalate
CAS No.	1187927-13-4
Molecular Formula	C10H17NO5 • C2H2O4
Molecular Weight	319.28 g/mol
Synonyms	(R)-Methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate oxalate; (R)-2-Amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid methyl ester oxalate; Methyl (R)-2-amino-2-(tetrahydropyran-4-yl)acetate oxalate; (R)-Amino(tetrahydropyran-4-yl)acetic acid methyl ester oxalate; (R)-ATPA Methyl Ester Oxalate; (R)-Methyl 2-amino-2-(oxan-4-yl)acetate oxalate
EINECS	Contact for details

Quality Control

Our (R)-Amino-(Tetrahydro-Pyran-4-Yl)-Acetic Acid Methyl Ester Oxalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.