Description

(3Ar,8Ar)-(-)-4,4,8,8-Tetrakis(3,5-Diethylphenyl) Tetrahydro-2,2-Dimethyl-6-Phenyl-1,3-Dioxolo [4,5-E]Dioxaphosphepin is a sophisticated chiral phosphine ligand, a key building block in advanced asymmetric catalysis. Its value lies in enabling highly selective chemical transformations, which are critical for producing enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-performance ligands for transition metal-catalyzed reactions such as hydrogenation, cross-coupling, and hydroformylation.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiopure pharmaceutical intermediates.
• Utilized in asymmetric cross-coupling and C-H activation reactions to construct complex chiral molecules.
• Critical component in the development of custom catalyst systems for process chemistry and scale-up in fine chemical production.
• Research and development of novel catalytic methodologies in academic and industrial laboratories.
• Potential use in the synthesis of agrochemicals and other bioactive compounds requiring high stereochemical control.
• As a reference standard for analytical method development and quality control of catalytic processes.

Basic Information

Product Name	(3Ar,8Ar)-(-)-4,4,8,8-Tetrakis(3,5-Diethylphenyl) Tetrahydro-2,2-Dimethyl-6-Phenyl-1,3-Dioxolo [4,5-E]Dioxaphosphepin
CAS No.	1187446-93-0
Molecular Formula	C55H73O4P
Molecular Weight	829.15 g/mol
Synonyms	(-)-Tetrahydro-2,2-dimethyl-6-phenyl-4,4,8,8-tetrakis(3,5-diethylphenyl)-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin; Chiral Dioxaphosphepin Ligand; (3aR,8aR)-4,4,8,8-Tetrakis(3,5-diethylphenyl)-2,2-dimethyl-6-phenyltetrahydro-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin; Asymmetric Phosphine Ligand; P-OP Type Bidentate Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure identity, purity, and enantiomeric excess. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity by HPLC, and residual solvent content. Our quality systems are designed to support cGMP requirements for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Under these conditions, the product is stable for extended periods. Handle and store under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.