Description

Methyl 8-Methyl-4-Hydroxy-5-Trifluoromethylquinoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its quinoline core and strategically positioned trifluoromethyl and ester functional groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing next-generation drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel quinoline-based drug candidates, including potential antivirals, antimicrobials, and anticancer agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Precursor: Serves as a starting material for creating specialized organic ligands, fluorinated dyes, or advanced organic electronic materials.
• Chemical Synthesis: Utilized in organic chemistry research for constructing complex heterocyclic frameworks and studying structure-activity relationships (SAR).
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.

Basic Information

Product Name	Methyl 8-Methyl-4-Hydroxy-5-Trifluoromethylquinoline-2-Carboxylate
CAS No.	1187386-20-4
Molecular Formula	C₁₃H₁₀F₃NO₃
Molecular Weight	285.22 g/mol
Synonyms	Methyl 4-hydroxy-8-methyl-5-(trifluoromethyl)quinoline-2-carboxylate; 5-Trifluoromethyl-8-methyl-4-hydroxyquinoline-2-carboxylic acid methyl ester; 8-Methyl-4-hydroxy-5-trifluoromethylquinoline-2-carboxylic acid methyl ester; 2-Quinolinecarboxylic acid, 4-hydroxy-8-methyl-5-(trifluoromethyl)-, methyl ester; Methyl 4-hydroxy-8-methyl-5-trifluoromethyl-2-quinolinecarboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 8-Methyl-4-Hydroxy-5-Trifluoromethylquinoline-2-Carboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Our quality system is designed to guarantee batch-to-batch consistency and reliable supply for critical development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.