Description

1-(2,4-Difluorophenyl)Cyclopropylamine Hydrochloride is a high-purity, pharmaceutically relevant building block and intermediate. This compound is valued for its unique cyclopropylamine core and difluorophenyl substitution, which are key motifs in modern medicinal chemistry for modulating biological activity and metabolic stability. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those targeting protease enzymes or G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to improve potency and pharmacokinetic properties.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key chiral precursor or core scaffold in the multi-step synthesis of potential APIs.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for investigating biological pathways and target validation.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and scale-up activities.
• Agrochemical Research: Potential application as an intermediate in the development of advanced crop protection agents with novel modes of action.

Basic Information

Product Name	1-(2,4-Difluorophenyl)Cyclopropylamine Hydrochloride
CAS No.	1186663-18-2
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	1-(2,4-Difluorophenyl)cyclopropanamine hydrochloride; 1-(2,4-Difluorophenyl)cyclopropylamine HCl; Cyclopropanamine, 1-(2,4-difluorophenyl)-, hydrochloride; 2,4-Difluoro-1-cyclopropylaminobenzene hydrochloride; (1-(2,4-Difluorophenyl)cyclopropyl)amine hydrochloride; 1-Cyclopropylamino-2,4-difluorobenzene hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,4-Difluorophenyl)Cyclopropylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for pre-clinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.