Description

1-(tert-Butyl)-6-Methyl-4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a trifluoromethyl group. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. Pharmaceutical R&D and manufacturing organizations need this specialized intermediate to develop next-generation drugs, leveraging its unique chemical properties to enhance drug efficacy, selectivity, and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel small-molecule drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used by research institutions and pharmaceutical companies for structure-activity relationship (SAR) studies and lead optimization programs.
• API Development: Incorporated into the core scaffold of investigational new drugs (INDs) to impart favorable pharmacokinetic properties via the trifluoromethyl and tert-butyl functional groups.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for cGMP production of clinical trial materials and commercial APIs.
• Chemical Biology Probes: Utilized in the development of chemical probes for target validation and pathway analysis in biological systems.
• Agrochemical Intermediate: Potential application as an intermediate in the synthesis of advanced crop protection agents, leveraging its heterocyclic framework.

Basic Information

Product Name	1-(tert-Butyl)-6-Methyl-4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxamide
CAS No.	1186404-79-4
Molecular Formula	C15H16F3N3O
Molecular Weight	311.30 g/mol
Synonyms	1-(tert-Butyl)-6-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 1-tert-Butyl-6-methyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, 1-(1,1-dimethylethyl)-6-methyl-4-(trifluoromethyl)-; 1186404-79-4; 1-(tert-butyl)-6-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide; 1-(tert-Butyl)-6-Methyl-4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxamide; 1-(tert-butyl)-6-methyl-4-(trifluoromethyl)pyrrolo[2,3-b]pyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyl)-6-Methyl-4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity, meeting the stringent requirements for pharmaceutical R&D and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and full spectroscopic characterization (NMR, MS, HPLC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference material
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.