Description

3-(Difluoromethyl)Quinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the difluoromethyl group can dramatically influence biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting kinase inhibitors, anti-infectives, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, where the quinoline scaffold and fluorine atoms contribute to herbicidal or fungicidal activity.
• Material Science Research: Serves as a precursor for developing novel organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Proteomics: Employed as a specialty reagent for creating chemical probes and inhibitors to study enzyme function and biological pathways.
• Catalyst & Ligand Development: Utilized in the synthesis of novel nitrogen-containing ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up services for clients requiring fluorinated quinoline derivatives.

Basic Information

Product Name	3-(Difluoromethyl)Quinoline
CAS No.	1186195-11-8
Molecular Formula	C10H7F2N
Molecular Weight	179.17 g/mol
Synonyms	Quinoline, 3-(difluoromethyl)-; 3-(Difluoromethyl)quinoline; 3-Difluoromethylquinoline; 1186195-11-8; Difluoromethylquinoline; 3-Quinolyl(difluoro)methane
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Quinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and MS confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.