Description

[4-(Tetrahydro-2H-Pyran-2-Ylmethoxy)Phenyl]Amine Hydrochloride is a high-purity, protected aniline derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: A monomer or precursor for advanced polymers and functional materials with specific optical or electronic properties.
• Peptidomimetics: Incorporated into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Used to create tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	[4-(Tetrahydro-2H-Pyran-2-Ylmethoxy)Phenyl]Amine Hydrochloride
CAS No.	1185690-98-5
Molecular Formula	C12H18ClNO2
Molecular Weight	243.73 g/mol
Synonyms	4-(Tetrahydro-2H-pyran-2-ylmethoxy)aniline hydrochloride; 4-(THP-O-Methoxy)aniline HCl; 4-(Tetrahydropyran-2-ylmethoxy)phenylamine hydrochloride; 4-(2-Tetrahydropyranylmethoxy)aniline hydrochloride; 4-[(Tetrahydro-2H-pyran-2-yl)methoxy]benzenamine hydrochloride; Aniline, 4-[(tetrahydro-2H-pyran-2-yl)methoxy]-, hydrochloride; THP-Protected 4-Aminophenol Hydrochloride
EINECS	Contact for details

Quality Control

Our [4-(Tetrahydro-2H-Pyran-2-Ylmethoxy)Phenyl]Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.