Description

2-(Fmoc-Amino)Benzeneacetic Acid is a protected amino acid derivative of significant importance in modern synthetic chemistry. This compound serves as a crucial building block for the solid-phase peptide synthesis (SPPS) of peptides containing phenylglycine analogs, enabling the creation of complex biomolecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic peptides, peptidomimetics, and other bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated or manual synthesis of peptides, particularly those incorporating modified phenylglycine residues.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide-based drugs, hormone analogs, and diagnostic agents.
• Peptidomimetic Design: Used to introduce constrained or unnatural amino acid motifs into peptide backbones to enhance stability, bioavailability, and target specificity.
• Bioconjugation and Labeling: The carboxylic acid group allows for conjugation to other molecules, carriers, or fluorescent labels for creating probes and targeted delivery systems.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Academic and Industrial Research: A fundamental reagent for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	2-(Fmoc-Amino)Benzeneacetic Acid
CAS No.	1185303-23-4
Molecular Formula	C23H19NO4
Molecular Weight	373.40 g/mol
Synonyms	Fmoc-2-Aminophenylacetic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminophenylacetic Acid; 2-[(9-Fluorenylmethoxycarbonyl)amino]benzeneacetic Acid; (2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}phenyl)acetic Acid; Fmoc-Pheg-OH; Fmoc-α-Aminophenylacetic Acid; N-Fmoc-2-aminophenylacetic Acid
EINECS	Contact for details

Quality Control

Our 2-(Fmoc-Amino)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.