Description

Fmoc-2-Amino-3,5-Dimethylbenzoic Acid CAS NO 1185302-84-4 is a protected amino acid derivative, specifically an Fmoc-protected ortho-aminobenzoic acid building block. This compound is essential for the solid-phase peptide synthesis (SPPS) of peptides containing non-natural or sterically hindered amino acid residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, including hormone analogs and enzyme inhibitors.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Bioconjugation: Serves as a linker or modified amino acid for attaching peptides to other molecules, surfaces, or carriers.
• Proteomics & Biochemical Tool Development: Integral for creating custom peptide substrates, inhibitors, or affinity tags for enzyme studies.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Fmoc-2-Amino-3,5-Dimethylbenzoic Acid
CAS No.	1185302-84-4
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	Fmoc-2-Amino-3,5-dimethylbenzoic acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,5-dimethylbenzoic acid; N-Fmoc-2-amino-3,5-dimethylbenzoic acid; Fmoc-2-A-3,5-DMBA; N-(9-Fluorenylmethoxycarbonyl)-2-amino-3,5-dimethylbenzoic acid; 3,5-Dimethyl-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]benzoic acid; Fmoc-D-2-Abz(3,5-Me)-OH (common peptide notation)
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-3,5-Dimethylbenzoic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. All batches undergo rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.