Description

Fmoc-2-Amino-3,4-Dimethylbenzoic Acid is a protected amino acid derivative, specifically an Fmoc-protected ortho-aminobenzoic acid, essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing modified aromatic amino acid residues into peptide chains, enabling the creation of complex, non-natural peptides with tailored properties. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research: Used in the development of novel peptide-based drugs, hormone analogs, and targeted therapeutics.
• Peptidomimetic Design: Incorporation of the 3,4-dimethyl-substituted aromatic ring allows for the study of structure-activity relationships (SAR) and the enhancement of peptide stability and bioavailability.
• Bioconjugation: The carboxylic acid group can be activated for coupling to other molecules, such as proteins, labels, or solid supports, to create conjugates for diagnostic or research purposes.
• Chemical Biology Probes: Serves as a precursor for synthesizing activity-based probes or photoaffinity labels to study enzyme function and protein-protein interactions.
• Material Science: Potential use in creating functionalized surfaces or peptide-based biomaterials.

Basic Information

Product Name	Fmoc-2-Amino-3,4-Dimethylbenzoic Acid
CAS No.	1185302-78-6
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	Fmoc-2-Abz(3,4-diMe)-OH; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,4-dimethylbenzoic acid; N-Fmoc-2-amino-3,4-dimethylbenzoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-dimethylanthranilic acid; Fmoc-3,4-dimethyl-2-aminobenzoic acid; Fmoc-DMAT-OH; (2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,4-dimethylbenzoic acid)
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-3,4-Dimethylbenzoic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.