Description

1,4'-Bipiperidine-4-Carboxylic Acid Dihydrochloride is a high-purity, pharmaceutically relevant building block and salt form of a versatile heterocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Chemical Biology Probe Synthesis: Serves as a scaffold for creating molecular probes to study biological pathways and protein function.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries to identify new bioactive molecules.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Salt Formation & Polymorph Studies: The dihydrochloride salt form is studied to optimize the physical and chemical properties of a drug substance, such as stability and solubility.

Basic Information

Product Name	1,4'-Bipiperidine-4-Carboxylic Acid Dihydrochloride
CAS No.	1185298-80-9
Molecular Formula	C11H20N2O2 · 2HCl
Molecular Weight	293.21 g/mol (Free base: 212.29)
Synonyms	4-(Piperidin-4-yl)piperidine-4-carboxylic acid dihydrochloride; 4-Carboxy-1,4'-bipiperidine dihydrochloride; 1,4'-Bipiperidine-4-carboxylic acid, hydrochloride (1:2); UNII-4Q8I7P6G6C; 4-Piperidinecarboxylic acid, 4-(4-piperidinyl)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 1,4'-Bipiperidine-4-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm
Chloride Content	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.