Description

Fmoc-2-Amino-6-Fluorobenzoic Acid is a high-purity, fluorinated aromatic amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound serves as a critical specialty building block for the solid-phase synthesis of complex peptides and modified biomolecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics research, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: As a key Fmoc-protected amino acid for introducing a fluorinated aromatic moiety into peptide sequences during SPPS (Solid-Phase Peptide Synthesis).
• Pharmaceutical Intermediates: Serves as a crucial precursor in the research and development of active pharmaceutical ingredients (APIs) with fluorinated aromatic structures.
• Chemical Biology Probes: Used to synthesize fluorophore-labeled or structurally modified peptides for studying protein-protein interactions and enzyme activity.
• Combinatorial Chemistry: A valuable building block for creating diverse chemical libraries in drug screening and lead optimization processes.
• Agrochemical Research: Potential intermediate in the development of novel herbicides or pesticides that incorporate fluorinated benzoic acid motifs.
• Material Science: Can be employed in the synthesis of specialized polymers or dendrimers with unique optical or electronic properties.

Basic Information

Item	Details
Product Name	Fmoc-2-Amino-6-Fluorobenzoic Acid
CAS No.	1185296-64-3
Molecular Formula	C22H16FNO4
Molecular Weight	377.37 g/mol
Synonyms	2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-6-fluorobenzoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-6-fluorobenzoic Acid; N-Fmoc-2-amino-6-fluorobenzoic Acid; Fmoc-2-Abz(6-F)-OH; 2-(Fmoc-amino)-6-fluorobenzoic Acid; 6-Fluoro-2-[(9-fluorenylmethoxycarbonyl)amino]benzoic Acid; 2-Amino-6-fluorobenzoic acid Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-6-Fluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere (argon or nitrogen) after each use to maintain purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.