Description

4-Quinolinemethanol, 2,6-Bis(Trifluoromethyl)- is a high-value, multi-functional fluorinated quinoline derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for complex organic synthesis. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its unique trifluoromethylated quinoline scaffold into novel molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Building block for developing new generation pesticides and herbicides, where the CF3 groups enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Used in organometallic chemistry to create novel ligands for catalysis, leveraging the nitrogen heterocycle for metal coordination.
• Material Science: Intermediate for synthesizing specialty polymers, organic semiconductors, or liquid crystals where fluorination modifies electronic properties and solubility.
• Chemical Biology Probe: Serves as a core structure for developing fluorescent probes or enzyme inhibitors in biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis of complex, fluorinated target molecules.

Basic Information

Product Name	4-Quinolinemethanol, 2,6-Bis(Trifluoromethyl)-
CAS No.	1185292-81-2
Molecular Formula	C12H7F6NO
Molecular Weight	295.18 g/mol
Synonyms	2,6-Bis(trifluoromethyl)-4-quinolinemethanol; (2,6-Bis(trifluoromethyl)quinolin-4-yl)methanol; 4-(Hydroxymethyl)-2,6-bis(trifluoromethyl)quinoline; 2,6-Bis(trifluoromethyl)-4-quinolinecarbinol; Quinolin-4-ylmethanol, 2,6-bis(trifluoromethyl)-; 2,6-Bis(trifluoromethyl)quinoline-4-methanol
EINECS	Contact for details

Quality Control

Our 4-Quinolinemethanol, 2,6-Bis(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support development projects with GMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.