Description

2-(Trifluoromethyl)Quinoline-4-Carbohydrazide is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline scaffold and trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile building block for creating novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting infectious diseases or central nervous system disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its privileged quinoline structure.
• Agrochemical Development: Employed in the research and synthesis of new active ingredients for crop protection products.
• Ligand and Catalyst Synthesis: Utilized in the preparation of specialized ligands for metal-catalyzed reactions or as a component in catalyst design.
• Fluorinated Compound Libraries: Acts as a valuable source of the trifluoromethyl group for creating fluorinated compound libraries, enhancing metabolic stability and lipophilicity in lead optimization.

Basic Information

Product Name	2-(Trifluoromethyl)Quinoline-4-Carbohydrazide
CAS No.	1185292-58-3
Molecular Formula	C₁₁H₈F₃N₃O
Molecular Weight	255.20 g/mol
Synonyms	2-(Trifluoromethyl)-4-quinolinecarbohydrazide; 4-Quinolinecarbohydrazide, 2-(trifluoromethyl)-; Quinoline-4-carbohydrazide, 2-(trifluoromethyl)-; 2-Trifluoromethylquinoline-4-carboxylic acid hydrazide; 2-CF3-Quinoline-4-carbohydrazide
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Quinoline-4-Carbohydrazide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.