Description

4-Quinolinecarboxylic Acid, 2-(Trifluoromethyl)-, Ethyl Ester is a high-value, fluorinated quinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of the trifluoromethyl group can dramatically alter biological activity and metabolic stability. Its primary utility lies in the synthesis of complex molecules for the pharmaceutical, agrochemical, and material science industries, enabling the creation of compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group improves lipophilicity and biological efficacy.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions, cyclizations, and as a scaffold for constructing more complex heterocyclic systems in process chemistry and R&D.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.

Basic Information

Product Name	4-Quinolinecarboxylic Acid, 2-(Trifluoromethyl)-, Ethyl Ester
CAS No.	1185292-57-2
Molecular Formula	C13H10F3NO2
Molecular Weight	269.22 g/mol
Synonyms	Ethyl 2-(Trifluoromethyl)quinoline-4-carboxylate; 2-Trifluoromethyl-quinoline-4-carboxylic acid ethyl ester; Quinoline-4-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester; 4-Carbethoxy-2-trifluoromethylquinoline; 2-CF3-Quinoline-4-carboxylic Acid Ethyl Ester; Ethyl 2-Trifluoromethyl-4-quinolinecarboxylate; 2-(Trifluoromethyl)-4-quinolinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Quinolinecarboxylic Acid, 2-(Trifluoromethyl)-, Ethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data with each shipment. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are generated using validated methods including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.