Description

1-(2,2,2-Trifluoro-Ethyl)-1H-Pyrazol-4-Ylamine Hydrochloride is a high-purity, fluorinated pyrazole derivative hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a trifluoroethyl-substituted pyrazole amine scaffold, which is essential for modulating the physicochemical and metabolic properties of target molecules. This intermediate is primarily needed by pharmaceutical R&D and agrochemical companies for the development of novel active ingredients, where the introduction of fluorine atoms is a key strategy to enhance potency, stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoroethyl group contributes to improved biological activity and environmental profile.
• Material Science Research: Employed in the synthesis of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for designing molecular probes and enzyme inhibitors to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom chemical synthesis services at milligram to kilogram scales.

Basic Information

Product Name	1-(2,2,2-Trifluoro-Ethyl)-1H-Pyrazol-4-Ylamine Hydrochloride
CAS No.	1185177-94-9
Molecular Formula	C5H7ClF3N3
Molecular Weight	201.58 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-1H-pyrazol-4-amine hydrochloride; 4-Amino-1-(2,2,2-trifluoroethyl)-1H-pyrazole hydrochloride; 1H-Pyrazol-4-amine, 1-(2,2,2-trifluoroethyl)-, hydrochloride; 1-(Trifluoroethyl)-1H-pyrazol-4-amine HCl; 1185177-94-9; 1-(2,2,2-Trifluoroethyl)-4-aminopyrazole hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoro-Ethyl)-1H-Pyrazol-4-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.