Description

4-(Difluoromethoxy)-2-Methylaniline Hydrochloride is a specialized aromatic amine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique difluoromethoxy and methyl-substituted aniline structure, which is essential for modulating the biological activity and physicochemical properties of target molecules. This high-purity intermediate is primarily needed by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the difluoromethoxy group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and molecular recognition applications.
• Material Science Research: Acts as a monomer or functionalization agent in the development of advanced polymers and functional materials.
• Chemical Biology Probes: Utilized to create fluorescent tags or affinity probes for studying biological mechanisms.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity aromatic amines.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Methylaniline Hydrochloride
CAS No.	1185175-00-1
Molecular Formula	C8H10F2NO•HCl
Molecular Weight	209.63 g/mol (Free base: 173.17 g/mol)
Synonyms	2-Methyl-4-(difluoromethoxy)aniline hydrochloride; 4-(Difluoromethoxy)-2-methylbenzenamine hydrochloride; 2-Methyl-4-(difluoromethoxy)phenylamine hydrochloride; 4-Amino-3-methylphenyl difluoromethyl ether hydrochloride; 2-Methyl-4-difluoromethoxyaniline HCl; Aniline, 4-(difluoromethoxy)-2-methyl-, hydrochloride; Benzenamine, 4-(difluoromethoxy)-2-methyl-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Methylaniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.