Description

4-Iodo-3-Methoxyaniline Hydrochloride is a halogenated aniline derivative, specifically the hydrochloride salt of a substituted aniline, which serves as a versatile and critical building block in advanced organic synthesis. Its value lies in its dual functional groups—the iodine substituent and the primary amine—which enable a range of cross-coupling and derivatization reactions essential for constructing complex molecular architectures. This intermediate is particularly sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing antimicrobial properties.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the reactivity of the iodine atom for structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, dyes, and liquid crystals.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form biaryl or alkyne-linked structures.
• Chemical Biology & Proteomics: Can be utilized as a tagging or labeling reagent for biomolecules due to the amine group's ability to form stable conjugates.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological development and exploratory chemistry projects.

Basic Information

Product Name	4-Iodo-3-Methoxyaniline Hydrochloride
CAS No.	1185168-45-9
Molecular Formula	C7H9ClINO
Molecular Weight	285.51 g/mol
Synonyms	3-Methoxy-4-iodoaniline hydrochloride; 4-Amino-2-iodoanisole hydrochloride; 2-Iodo-5-methoxyaniline hydrochloride; 4-Iodo-3-methoxybenzenamine hydrochloride; 1-Amino-4-iodo-2-methoxybenzene hydrochloride; 5-Methoxy-2-iodoaniline hydrochloride; Aniline, 4-iodo-3-methoxy-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Iodo-3-Methoxyaniline Hydrochloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, impurity profile, and residual solvents. We are committed to consistent quality and supply chain reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.