Description

4-[2-(4-Morpholinyl)Ethoxy]-3-(Trifluoromethyl)-Phenylamine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its morpholine and trifluoromethyl functional groups. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing therapeutics for oncology, central nervous system (CNS) disorders, and other specialized areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential drug candidates, especially those targeting protein kinases and other enzymes.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• API Development: Employed in the pilot-scale and commercial-scale production of active pharmaceutical ingredients for clinical trials and eventual manufacturing.
• Biochemical Tool Compound: May be utilized in biochemical assays and as a reference standard for analytical method development and validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke synthesis services for client-specific molecules.

Basic Information

Product Name	4-[2-(4-Morpholinyl)Ethoxy]-3-(Trifluoromethyl)-Phenylamine Dihydrochloride
CAS No.	1185130-96-4
Molecular Formula	C13H18Cl2F3N2O2
Molecular Weight	359.20 g/mol
Synonyms	4-[2-(Morpholin-4-yl)ethoxy]-3-(trifluoromethyl)aniline dihydrochloride; 3-(Trifluoromethyl)-4-[2-(4-morpholinyl)ethoxy]benzenamine dihydrochloride; 4-(2-Morpholinoethoxy)-3-(trifluoromethyl)aniline dihydrochloride; 4-Amino-2-(2-morpholin-4-ylethoxy)benzotrifluoride dihydrochloride; 1185130-96-4; UNII-9J8F8Y6V6P; 9J8F8Y6V6P
EINECS	Contact for details

Quality Control

Our 4-[2-(4-Morpholinyl)Ethoxy]-3-(Trifluoromethyl)-Phenylamine Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.