Description

2-[4-(Trifluoromethyl)Phenyl] Thiomorpholine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylphenyl-thiomorpholine scaffold. This compound is of significant commercial importance for its role in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating new drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged thiomorpholine structure and fluorine substitution.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel pesticides and herbicides, leveraging the bioactivity of the trifluoromethyl group.
• Ligand and Catalyst Synthesis: Utilized in the preparation of specialized ligands for catalysis or as a component in material science research.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-[4-(Trifluoromethyl)Phenyl] Thiomorpholine Hydrochloride
CAS No.	1185044-02-3
Molecular Formula	C11H12F3NS • HCl
Molecular Weight	277.74 g/mol (Free base: 241.28 g/mol)
Synonyms	2-[4-(Trifluoromethyl)phenyl]thiomorpholine hydrochloride; 4-(Trifluoromethyl)phenyl-thiomorpholine HCl; Thiomorpholine, 2-[4-(trifluoromethyl)phenyl]-, hydrochloride; 2-(4-Trifluoromethylphenyl)thiomorpholine hydrochloride; CAS 1185044-02-3
EINECS	Contact for details

Quality Control

Our production of 2-[4-(Trifluoromethyl)Phenyl] Thiomorpholine HCl adheres to stringent quality management protocols. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.