Description

5,7-Dichlorokynurenic Acid Sodium Salt is a high-purity, selective NMDA receptor glycine site antagonist. This compound is a critical research-grade chemical for investigating glutamatergic neurotransmission and its role in neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) focused on neuropharmacology and CNS drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of NMDA receptors in synaptic plasticity, learning, and memory.
• Neuropharmacology Screening: Used in in vitro and in vivo assays to evaluate potential neuroprotective agents targeting excitotoxicity.
• Mechanistic Studies: Investigating pathways related to stroke, traumatic brain injury, epilepsy, and chronic neurodegenerative diseases like Alzheimer's and Parkinson's.
• Biochemical Assay Development: Serves as a reference standard and active control in high-throughput screening (HTS) platforms for receptor binding studies.
• Academic & Institutional Research: Fundamental research in university and government laboratories exploring CNS function and dysfunction.

Basic Information

Product Name	5,7-Dichlorokynurenic Acid Sodium Salt
CAS No.	1184986-70-6
Molecular Formula	C10H3Cl2NNaO3
Molecular Weight	286.04 g/mol
Synonyms	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt; DNQX sodium salt (common abbreviation); 5,7-Dichlorokynurenate sodium; Sodium 5,7-dichloro-4-hydroxyquinoline-2-carboxylate; 5,7-DCKA sodium salt; DNQX-Na; NMDA receptor glycine site antagonist
EINECS	Contact for details

Quality Control

Every batch of 5,7-Dichlorokynurenic Acid Sodium Salt is manufactured under strict quality management protocols. We guarantee high chemical purity and batch-to-batch consistency suitable for sensitive research applications. Comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, is performed. A detailed Certificate of Analysis (COA) with lot-specific data is provided with each shipment to ensure full traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.