Description

5-(Bromomethyl)-1-(Phenylsulfonyl)-1H-Indole is a high-value, multi-functional indole derivative that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a reactive bromomethyl handle and a phenylsulfonyl-protected indole nitrogen, makes it an indispensable intermediate for constructing complex heterocyclic frameworks. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of biologically active indole-based compounds, including potential kinase inhibitors and receptor modulators.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by incorporating the indole scaffold into lead structures.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialized polymers and organic electronic materials.
• Cross-Coupling Reactions: The bromomethyl group is an excellent electrophile for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce complex side chains.
• Nucleophilic Substitution: Reacts with various nucleophiles (amines, thiols, alkoxides) to generate diversely functionalized indole derivatives for library synthesis.
• Protecting Group Strategy: The phenylsulfonyl group on the indole nitrogen allows for selective functionalization at other positions, which can later be deprotected.

Basic Information

Product Name	5-(Bromomethyl)-1-(Phenylsulfonyl)-1H-Indole
CAS No.	1184953-71-6
Molecular Formula	C15H12BrNO2S
Molecular Weight	350.23 g/mol
Synonyms	1H-Indole, 5-(bromomethyl)-1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-5-(bromomethyl)indole; 5-Bromomethyl-1-phenylsulfonylindole; 5-(Bromomethyl)-1-(benzenesulfonyl)-1H-indole; 1-Benzenesulfonyl-5-bromomethylindole; 5-Bromomethyl-1H-indole-1-sulfonic Acid Phenyl Ester; 1-(Phenylsulfonyl)-5-(bromomethyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)-1-(Phenylsulfonyl)-1H-Indole is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.