Description

tert-Butyl 6-Oxo-2-Azaspiro[3.3]heptane-2-carboxylate is a high-value, protected spirocyclic amino acid derivative that serves as a critical building block in modern organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the construction of novel, three-dimensional molecular scaffolds with potential therapeutic activity. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers for the synthesis of complex drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Used to construct the linker or warhead components of bifunctional PROTAC molecules for targeted protein degradation.
• Peptidomimetic Chemistry: Incorporates a constrained, spirocyclic structure into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and probes to study enzyme function and biological pathways.
• Agrochemical Research: Employed in the discovery and synthesis of new agrochemicals with novel modes of action.
• Academic & Contract Research: Utilized in academic institutions and CROs (Contract Research Organizations) for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	tert-Butyl 6-Oxo-2-Azaspiro[3.3]heptane-2-Carboxylate
CAS No.	1181816-12-5
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester; 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Boc-6-oxo-2-azaspiro[3.3]heptane; tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate; 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-one; 2-Boc-2-azaspiro[3.3]heptan-6-one; 2-Azaspiro[3.3]heptan-6-one, 2-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Oxo-2-Azaspiro[3.3]heptane-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.