Description

3-Azabicyclo[3.1.0]Hexane-1-Carboxylic Acid Hydrochloride is a high-purity, bicyclic proline derivative that serves as a critical chiral building block in advanced organic synthesis. Its constrained, rigid structure is essential for modulating the conformational and pharmacological properties of target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in CNS drug discovery.
• Peptidomimetics & Constrained Amino Acid Analogue: Used to introduce conformational rigidity into peptide chains, enhancing metabolic stability and receptor selectivity.
• Agrochemical Research: Serves as a building block for creating new generation herbicides and fungicides with specific stereochemical requirements.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme mechanisms and protein-protein interactions.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research laboratories.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-1-Carboxylic Acid Hydrochloride
CAS No.	1181458-33-2
Molecular Formula	C7H11NO2 • HCl
Molecular Weight	177.63 g/mol
Synonyms	1-Carboxy-3-azabicyclo[3.1.0]hexane hydrochloride; (1R,5S)-3-Azabicyclo[3.1.0]hexane-1-carboxylic acid hydrochloride; (1S,5R)-3-Azabicyclo[3.1.0]hexane-1-carboxylic acid hydrochloride; Bicycloproline hydrochloride; 3-Aza-bicyclo[3.1.0]hexane-1-carboxylic acid HCl; 3-Azabicyclo[3.1.0]hexane-1-carboxylic acid HCl salt; Constrained Proline Derivative Hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]Hexane-1-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided for every shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.