Description

(1R)-1-[4-(Trifluoromethyl)Phenyl]-Prop-2-En-1-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, a key building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with a defined stereocenter, which is critical for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring enantiomerically pure intermediates. The CAS number for this compound is 1181394-23-9.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of enantiomerically pure active ingredients for herbicides, fungicides, and insecticides.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Material Science: Potential monomer or additive for creating specialty polymers with unique optical or electronic properties.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes to chiral targets in pilot plants and kilo labs.

Basic Information

Product Name	(1R)-1-[4-(Trifluoromethyl)Phenyl]-Prop-2-En-1-Amine Hydrochloride
CAS No.	1181394-23-9
Molecular Formula	C10H11ClF3N
Molecular Weight	237.65 g/mol
Synonyms	(R)-1-(4-(Trifluoromethyl)phenyl)allylamine hydrochloride; (1R)-1-[4-(Trifluoromethyl)phenyl]prop-2-en-1-amine HCl; (R)-α-Methyl-4-(trifluoromethyl)benzylamine hydrochloride (allyl derivative); (R)-1-(4-Trifluoromethylphenyl)allylamine HCl; (R)-TFMPAA hydrochloride; (R)-4-Trifluoromethylcinnamylamine hydrochloride; (R)-1-(4-CF3-Phenyl)-2-propen-1-amine hydrochloride; (R)-1-(p-Trifluoromethylphenyl)allylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-1-[4-(Trifluoromethyl)Phenyl]-Prop-2-En-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, chiral integrity, and consistent performance. Specifications are aligned with standards suitable for pharmaceutical R&D and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.