Description

3-Amino-4-(2,2-Difluoroethoxy)Benzoic Acid is a specialized aromatic compound featuring both an amino and a carboxylic acid functional group, differentiated by a unique 2,2-difluoroethoxy side chain. This distinct molecular architecture makes it a valuable high-purity building block for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for creating targeted molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial precursor in multi-step synthetic routes for constructing complex API molecules.
• Bioconjugation & Probe Development: Utilized in creating fluorescent probes or affinity labels for biochemical research and diagnostic applications due to its reactive amine and acid groups.
• Ligand & Catalyst Design: Employed in the synthesis of specialized ligands for metal-organic frameworks (MOFs) or asymmetric catalysis.
• Material Science Research: Used as a monomer or functionalizing agent in the development of novel polymers with specific fluorinated properties.
• Agrochemical Intermediate: Potential use in the synthesis of advanced, fluorinated agrochemicals requiring specific bioactivity.

Basic Information

Product Name	3-Amino-4-(2,2-Difluoroethoxy)Benzoic Acid
CAS No.	1178372-80-9
Molecular Formula	C9H9F2NO3
Molecular Weight	217.17 g/mol
Synonyms	3-Amino-4-(2,2-difluoroethoxy)benzoic acid; Benzoic acid, 3-amino-4-(2,2-difluoroethoxy)-; 4-(2,2-Difluoroethoxy)-3-aminobenzoic acid; 3-Amino-4-(2,2-difluoroethoxy)benzoic acid CAS 1178372-80-9; 2,2-Difluoroethoxy-3-aminobenzoic acid; DFEB Acid; 3-A-4-DFEBA
EINECS	Contact for details

Quality Control

Our production of 3-Amino-4-(2,2-Difluoroethoxy)Benzoic Acid adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal quality standards. Specifications can be aligned with current Good Manufacturing Practice (cGMP) principles for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.