Description

4-(2,2-Difluoroethoxy)-3-Nitro-Benzoic Acid is a high-purity, synthetically valuable benzoic acid derivative featuring a difluoroethoxy and a nitro substituent. This compound serves as a critical pharmaceutical intermediate and advanced building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is essential for research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to introduce specific fluorine-containing motifs into target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or other therapeutic areas where the difluoroethoxy group modulates pharmacokinetic properties.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, or insecticides, leveraging the bioactivity imparted by the nitro and fluorine-containing groups.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, or organic electronic materials where its specific substitution pattern can influence material properties.
• Chemical Biology & Proteomics: Acts as a specialty reagent for designing molecular probes, affinity labels, or linker molecules in biochemical research.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise fluorinated scaffold.

Basic Information

Product Name	4-(2,2-Difluoroethoxy)-3-Nitro-Benzoic Acid
CAS No.	1178286-57-1
Molecular Formula	C9H7F2NO5
Molecular Weight	247.15 g/mol
Synonyms	3-Nitro-4-(2,2-difluoroethoxy)benzoic acid; Benzoic acid, 4-(2,2-difluoroethoxy)-3-nitro-; 4-(2,2-Difluoroethoxy)-3-nitrobenzoic acid; 1178286-57-1; 4-(Difluoroethoxy)-3-nitrobenzoic acid
EINECS	Contact for details

Quality Control

Our production of 4-(2,2-Difluoroethoxy)-3-Nitro-Benzoic Acid adheres to stringent in-process and final release controls. Every batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.