Description

8-Piperazin-1-Yl-Quinoline, Dihydrochloride is a high-purity, synthetic organic compound primarily utilized as a key pharmaceutical intermediate. Its value lies in its role as a versatile building block for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research. This compound is essential for B2B clients in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex molecules for drug discovery programs, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) with potential biological activity.
• API Synthesis: Used in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), where its piperazine and quinoline moieties offer valuable functionalization points.
• Biochemical Research: Employed in biochemical assays and as a tool compound for investigating biological pathways and protein interactions in academic and industrial R&D settings.
• Fine Chemical Manufacturing: A specialized intermediate for the production of advanced, high-value fine chemicals and custom synthesis projects.

Basic Information

Product Name	8-Piperazin-1-Yl-Quinoline, Dihydrochloride
CAS No.	1177353-50-2
Molecular Formula	C₁₃H₁₈Cl₂N₄
Molecular Weight	301.21 g/mol
Synonyms	8-(Piperazin-1-yl)quinoline dihydrochloride; Quinoline, 8-(1-piperazinyl)-, dihydrochloride; 8-(1-Piperazinyl)quinoline dihydrochloride; 8-Piperazinylquinoline dihydrochloride; 1-(Quinolin-8-yl)piperazine dihydrochloride; 8-Quinolylpiperazine dihydrochloride; 1177353-50-2
EINECS	Contact for details

Quality Control

Our 8-Piperazin-1-Yl-Quinoline, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.