Description

5-Amino-1H-Indazole-3-Carboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant chemical building block essential for modern drug discovery and development. Its core value lies in its functionalized indazole scaffold, which serves as a privileged structure for synthesizing bioactive molecules targeting a range of therapeutic areas. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and targeted cancer therapies.
• Chemical Biology Research: Used as a scaffold or probe in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical building block in the multi-step synthesis of complex APIs under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	5-Amino-1H-Indazole-3-Carboxylic Acid Hydrochloride
CAS No.	1177307-67-3
Molecular Formula	C8H8N3O2·HCl
Molecular Weight	215.63 g/mol (Free base: 179.17 g/mol)
Synonyms	5-Amino-1H-indazole-3-carboxylic acid hydrochloride; 1H-Indazole-3-carboxylic acid, 5-amino-, hydrochloride; 5-Aminoindazole-3-carboxylic acid HCl; 3-Carboxy-5-aminoindazole hydrochloride; 5-Amino-1H-indazole-3-carboxylic acid HCl salt; 1177307-67-3; 5-Amino-3-indazolecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Amino-1H-Indazole-3-Carboxylic Acid Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems support compliance with relevant standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.