Description

5-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid is a high-value fluorinated pyrazine derivative, serving as a critical building block in advanced organic synthesis. Its trifluoromethyl and carboxylic acid functional groups make it a versatile intermediate for creating compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific fluorine-containing motifs.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and molecular probes for studying biological mechanisms and diagnostic applications.

Basic Information

Product Name	5-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid
CAS No.	1174321-06-2
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	2-Pyrazinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-pyrazinecarboxylic acid; 5-Trifluoromethylpyrazine-2-carboxylic acid; 5-Trifluoromethyl-2-pyrazinecarboxylic acid; 1174321-06-2; 5-(Trifluoromethyl)pyrazine-2-carboxylic acid; 5-(Trifluoromethyl)pyrazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture and light to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.