Description

Racemic-(1S,3S,4S,5R)-2-Benzyl 3-Ethyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex, rigid bicyclic structure. This compound is of significant commercial interest as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the fields of neurology and virology. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of complex small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the research and development of new drug candidates targeting the central nervous system.
• Neurological Drug Synthesis: Used as a precursor in the synthesis of potential treatments for neurological disorders, leveraging its constrained bicyclic framework.
• Antiviral Agent Development: Employed in the construction of complex molecules being investigated for antiviral applications.
• Asymmetric Catalysis Research: Acts as a starting material or ligand precursor in the development of new asymmetric catalytic processes.
• Medicinal Chemistry Research: Provides a versatile, functionalized core structure for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Supplied for route scouting, process development, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	Racemic-(1S,3S,4S,5R)-2-Benzyl 3-Ethyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate
CAS No.	1173294-41-1
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	2-Azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 5-hydroxy-, 2-benzyl 3-ethyl ester, (1S,3S,4S,5R)-rel-; (±)-(1S,3S,4S,5R)-2-Benzyl 3-ethyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate; rel-(1S,3S,4S,5R)-2-Benzyl 3-ethyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate; 2-Benzyl 3-ethyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate (racemic); Bicyclic Proline Derivative; 1173294-41-1
EINECS	Contact for details

Quality Control

Our Racemic-(1S,3S,4S,5R)-2-Benzyl 3-Ethyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with material produced under cGMP guidelines for advanced phase requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (sum of enantiomers)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.