Description

cis-3-(2,5-Dimethylphenyl)-3-Hydroxy-8-Methoxy-1-Azaspiro[4.5]Decane-2,4-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and dione structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential neuroactive compounds and spirocyclic drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic & Institutional Research: Utilized in universities and research institutes for exploring new synthetic methodologies and bioactive molecules.
• Contract Research Organizations (CROs): Supplied to CROs conducting custom synthesis and preclinical development for client projects.

Basic Information

Product Name	cis-3-(2,5-Dimethylphenyl)-3-Hydroxy-8-Methoxy-1-Azaspiro[4.5]Decane-2,4-Dione
CAS No.	1172134-11-0
Molecular Formula	C21H27NO4
Molecular Weight	357.45 g/mol
Synonyms	3-Hydroxy-8-methoxy-3-(2,5-dimethylphenyl)-1-azaspiro[4.5]decane-2,4-dione; 1-Azaspiro[4.5]decane-2,4-dione, 3-(2,5-dimethylphenyl)-3-hydroxy-8-methoxy-, cis-; cis-3-Hydroxy-8-methoxy-3-(2,5-dimethylphenyl)-1-azaspiro[4.5]decane-2,4-dione; (3R,8S)-3-(2,5-Dimethylphenyl)-3-hydroxy-8-methoxy-1-azaspiro[4.5]decane-2,4-dione (stereoisomer); AZD-1283 Intermediate; Spirocyclic Dione Intermediate
EINECS	Contact for details

Quality Control

Our cis-3-(2,5-Dimethylphenyl)-3-Hydroxy-8-Methoxy-1-Azaspiro[4.5]Decane-2,4-Dione is manufactured under strict quality systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.