Description

1-{[1-(Difluoromethyl)-3,5-Dimethyl-1H-Pyrazol-4-Yl]Sulfonyl}Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl piperazine and difluoromethyl pyrazole structure. This compound matters as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. Research and development teams in the global pharmaceutical and agrochemical industries need this specialized intermediate for creating new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the difluoromethyl group for improved bioavailability and environmental profile.
• Chemical Biology Research: Serves as a versatile scaffold or probe in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• API Manufacturing: Employed in the scalable production of active pharmaceutical ingredients under current Good Manufacturing Practice (cGMP) conditions for clinical and commercial supply.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences market.

Basic Information

Product Name	1-{[1-(Difluoromethyl)-3,5-Dimethyl-1H-Pyrazol-4-Yl]Sulfonyl}Piperazine
CAS No.	1171977-38-0
Molecular Formula	C11H18F2N4O2S
Molecular Weight	308.35 g/mol
Synonyms	1-[(1-Difluoromethyl-3,5-dimethylpyrazol-4-yl)sulfonyl]piperazine; 1-({1-[(Difluoromethyl)-3,5-dimethyl-1H-pyrazol-4-yl]}sulfonyl)piperazine; Piperazine, 1-[[1-(difluoromethyl)-3,5-dimethyl-1H-pyrazol-4-yl]sulfonyl]-; 1171977-38-0; UNII-9V6C7Q4F8R; 9V6C7Q4F8R; SCHEMBL21827027; DTXSID90648669
EINECS	Contact for details

Quality Control

Our 1-{[1-(Difluoromethyl)-3,5-Dimethyl-1H-Pyrazol-4-Yl]Sulfonyl}Piperazine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring material for GMP and non-GMP development, with documentation traceability available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.