Description

3-Amino-1,1,1-Trifluoro-3-Phenylpropan-2-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl and amino alcohol functional groups. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile chiral building block for medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas such as central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used as a building block for constructing complex molecules in drug discovery programs, especially for CNS-targeted therapies.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides with fluorinated motifs.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal complexes.
• Fluorinated Compound Libraries: An essential component for creating screening libraries focused on fluorinated bioactive compounds.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	3-Amino-1,1,1-Trifluoro-3-Phenylpropan-2-Ol Hydrochloride
CAS No.	1171676-48-4
Molecular Formula	C9H9F3NO • HCl
Molecular Weight	243.63 g/mol (Free base: 207.17 g/mol)
Synonyms	3-Amino-1,1,1-trifluoro-3-phenyl-2-propanol hydrochloride; 3-Amino-3-phenyl-1,1,1-trifluoropropan-2-ol hydrochloride; 1,1,1-Trifluoro-3-amino-3-phenyl-2-propanol HCl; (R/S)-3-Amino-1,1,1-trifluoro-3-phenylpropan-2-ol hydrochloride; α-(Aminomethyl)-β,β,β-trifluorophenethyl alcohol hydrochloride; ATFPP-HCl; 3-Phenyl-3-(trifluoromethyl)aziridin-2-ol hydrochloride (tautomer)
EINECS	Contact for details

Quality Control

Our 3-Amino-1,1,1-Trifluoro-3-Phenylpropan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.