Description

1-(2,2-Difluoro-Ethyl)-5-Nitro-1H-Pyrazole is a specialized fluorinated pyrazole derivative, a high-value building block in advanced organic synthesis. Its unique structure, featuring both a difluoroethyl group and a nitro substituent, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating compounds with enhanced biological activity and specific physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, where the fluorine atoms can improve metabolic stability and membrane permeability.
• Chemical Research & Development: Used as a versatile building block in academic and industrial R&D for exploring new heterocyclic chemistry and fluorination methodologies.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials, such as ligands for catalysis or components for electronic materials.

Basic Information

Product Name	1-(2,2-Difluoro-Ethyl)-5-Nitro-1H-Pyrazole
CAS No.	1171325-18-0
Molecular Formula	C5H5F2N3O2
Molecular Weight	177.11 g/mol
Synonyms	1-(2,2-Difluoroethyl)-5-nitro-1H-pyrazole; 5-Nitro-1-(2,2-difluoroethyl)-1H-pyrazole; 1H-Pyrazole, 1-(2,2-difluoroethyl)-5-nitro-; 1171325-18-0; 1-(2,2-Difluoroethyl)-5-nitropyrazole
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoro-Ethyl)-5-Nitro-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.