Description

4-(5-Fluoro-2-Methoxy-Benzyl)-Piperidine Hydrochloride is a high-purity, non-racemic pharmaceutical intermediate and building block of significant commercial importance. Its value lies in its role as a key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. This compound is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic candidates with high stereochemical purity.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, especially in neurological and psychiatric disorder research.
• Active Pharmaceutical Ingredient (API) Development: Used in the R&D and scale-up of new chemical entities (NCEs) targeting specific receptors.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration by providing a defined, substituted piperidine scaffold.
• Process Chemistry & Route Scouting: Serves as a key intermediate for optimizing synthetic pathways for cost-effective and scalable API manufacturing.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in regulatory filings.
• Biochemical Research: Employed in biochemical assays and as a ligand or inhibitor probe in pharmacological studies.

Basic Information

Product Name	4-(5-Fluoro-2-Methoxy-Benzyl)-Piperidine Hydrochloride
CAS No.	1170474-15-3
Molecular Formula	C14H20ClFNO
Molecular Weight	287.77 g/mol
Synonyms	4-[(5-Fluoro-2-methoxyphenyl)methyl]piperidine hydrochloride; 1-(5-Fluoro-2-methoxybenzyl)piperidin-4-yl hydrochloride; 4-(5-Fluoro-2-methoxybenzyl)piperidine HCl; Piperidine, 4-[(5-fluoro-2-methoxyphenyl)methyl]-, hydrochloride (1:1); (5-Fluoro-2-methoxybenzyl)piperidine-4-yl hydrochloride; 1170474-15-3; 4-(5-Fluoro-2-methoxy-benzyl)-piperidine HCl
EINECS	Contact for details

Quality Control

Our 4-(5-Fluoro-2-Methoxy-Benzyl)-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) providing full specifications, including enantiomeric excess (ee), is supplied with every shipment to guarantee traceability, consistency, and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.