Description

8-Fluoro-4-Hydrazino-2-Methylquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1170457-07-4. This compound is a critical building block in the synthesis of complex heterocyclic molecules, valued for its precise reactivity and fluorine-substituted quinoline core. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring targeted molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the biological activity of the fluorinated quinoline structure.
• Chemical Synthesis Reagent: Serves as a versatile reagent for introducing the 4-hydrazinoquinoline moiety into more complex molecular architectures in medicinal chemistry.
• Material Science Research: Investigated as a potential building block for organic electronic materials and fluorescent dyes due to its conjugated quinoline system.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for method development and exploratory synthetic studies.

Basic Information

Product Name	8-Fluoro-4-Hydrazino-2-Methylquinoline Hydrochloride
CAS No.	1170457-07-4
Molecular Formula	C₁₁H₁₁FN₄·HCl
Molecular Weight	254.69 g/mol (Free base: 218.23 g/mol)
Synonyms	8-Fluoro-2-methyl-4-quinolinehydrazine hydrochloride; 4-Hydrazino-8-fluoro-2-methylquinoline hydrochloride; 2-Methyl-8-fluoro-4-hydrazinoquinoline HCl; 8-Fluoro-2-methylquinolin-4-ylhydrazine hydrochloride; 1170457-07-4; Quinoline, 8-fluoro-4-hydrazino-2-methyl-, hydrochloride; 4-Hydrazinyl-8-fluoro-2-methylquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4-Hydrazino-2-Methylquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.