Description

Ethyl 2-(4-(Trifluoromethylsulfonyloxy)Cyclohex-3-Enyl)Acetate is a high-value, advanced pharmaceutical intermediate characterized by its reactive trifluoromethanesulfonate (triflate) ester and cyclohexene functionalities. This compound matters for its role as a versatile building block in the synthesis of complex molecules, particularly in medicinal chemistry where its structure enables key carbon-carbon bond formation and functional group transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of potential drug candidates, particularly those requiring stereoselective modifications on a cyclohexane scaffold.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive triflate leaving group.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals where the cyclohexyl and ester groups contribute to specific material properties.
• Organic Synthesis Building Block: Facilitates nucleophilic substitution and elimination reactions in complex organic molecule construction for academic and industrial research.

Basic Information

Product Name	Ethyl 2-(4-(Trifluoromethylsulfonyloxy)Cyclohex-3-Enyl)Acetate
CAS No.	1166829-72-6
Molecular Formula	C11H15F3O5S
Molecular Weight	316.30 g/mol
Synonyms	Ethyl 2-[4-(Trifluoromethanesulfonyloxy)cyclohex-3-en-1-yl]acetate; 4-(Trifluoromethanesulfonyloxy)cyclohex-3-ene-1-acetic Acid Ethyl Ester; 3-Cyclohexene-1-acetic acid, 4-[(trifluoromethyl)sulfonyl]oxy]-, ethyl ester; Ethyl (4-((trifluoromethyl)sulfonyl)oxy)cyclohex-3-ene-1-yl)acetate; Triflate Ester Intermediate CAS 1166829-72-6
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-(Trifluoromethylsulfonyloxy)Cyclohex-3-Enyl)Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.