Description

4-Chloro-3,5-Difluorocinnamicacid is a halogenated cinnamic acid derivative, a high-value fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring chlorine and fluorine substituents, makes it a critical intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl and conjugated systems.
• Fluorine Chemistry Library: A valuable component for building diverse compound libraries in medicinal chemistry for high-throughput screening.

Basic Information

Product Name	4-Chloro-3,5-Difluorocinnamicacid
CAS No.	1163258-83-0
Molecular Formula	C9H5ClF2O2
Molecular Weight	218.59 g/mol
Synonyms	(E)-3-(4-Chloro-3,5-difluorophenyl)acrylic acid; 4-Chloro-3,5-difluorocinnamic acid; 3-(4-Chloro-3,5-difluorophenyl)-2-propenoic acid; (2E)-3-(4-Chloro-3,5-difluorophenyl)prop-2-enoic acid; 4-Chloro-3,5-difluorocinnamate; Cinnamic acid, 4-chloro-3,5-difluoro-; 1163258-83-0
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorocinnamicacid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.