Description

8-Chloro-2-(4-Methoxyphenyl)Quinoline-4-Carbonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive carbonyl chloride and halogenated quinoline core structure. This compound is essential for facilitating complex synthetic transformations in advanced research and development, offering a critical building block for creating novel molecular architectures. It is primarily sought after by pharmaceutical, agrochemical, and advanced material scientists for the synthesis of active pharmaceutical ingredients (APIs), specialty chemicals, and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, including potential antimicrobials, anticancer agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its halogenated quinoline scaffold for bioactivity.
• Material Science Research: Serves as a building block for creating organic semiconductors, luminescent materials, and metal-organic frameworks (MOFs) due to its conjugated system.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags, photoaffinity labels, and other molecular probes for biological target identification.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce diverse aryl/alkyl groups.
• Peptide Mimetics & Conjugation: The reactive acyl chloride group is utilized for amide bond formation, enabling the conjugation of the quinoline moiety to peptides or other biomolecules.

Basic Information

Product Name	8-Chloro-2-(4-Methoxyphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160263-65-9
Molecular Formula	C18H11Cl2NO2
Molecular Weight	344.19 g/mol
Synonyms	8-Chloro-2-(4-methoxyphenyl)-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 8-chloro-2-(4-methoxyphenyl)-; 2-(4-Methoxyphenyl)-8-chloroquinoline-4-carbonyl chloride; 8-Chloro-2-(p-methoxyphenyl)quinoline-4-carboxylic acid chloride; 1160263-65-9
EINECS	Contact for details

Quality Control

Our production of 8-Chloro-2-(4-Methoxyphenyl)Quinoline-4-Carbonyl Chloride adheres to stringent in-process controls and final batch testing to ensure consistent purity and identity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for assay, purity, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.