Description

7-Chloro-2-(3-Chlorophenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-purity, multi-functional quinoline derivative designed for advanced chemical synthesis. This compound matters as a critical building block in pharmaceutical research and development, offering a reactive carbonyl chloride group for efficient amide and ester bond formation. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the quinoline scaffold's bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed to create fluorescent tags or affinity probes for studying biological pathways and protein interactions.
• Catalyst Ligand Development: The quinoline structure can be modified to create novel ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses producing bespoke compounds for client R&D programs.

Basic Information

Product Name	7-Chloro-2-(3-Chlorophenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160263-58-0
Molecular Formula	C18H12Cl3NO
Molecular Weight	364.65 g/mol
Synonyms	4-Chlorocarbonyl-7-chloro-2-(3-chlorophenyl)-8-methylquinoline; 7-Chloro-2-(3-chlorophenyl)-8-methyl-4-quinolinecarbonyl chloride; 8-Methyl-7-chloro-2-(3-chlorophenyl)quinoline-4-carbonyl chloride; 2-(3-Chlorophenyl)-7-chloro-8-methylquinoline-4-carbonyl chloride; Quinoline-4-carbonyl chloride, 7-chloro-2-(3-chlorophenyl)-8-methyl-
EINECS	Contact for details

Quality Control

Our 7-Chloro-2-(3-Chlorophenyl)-8-Methylquinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.