Description

8-Chloro-2-(2-Methylphenyl)Quinoline-4-Carbonyl Chloride is a high-purity, multi-functional chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in its dual reactive sites—the acid chloride and the halogenated quinoline core—which enable its use as a critical building block for constructing complex molecular architectures. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for API synthesis and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the quinoline scaffold for biological activity.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of organic semiconductors, luminescent materials, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create fluorescent tags or affinity probes for studying biological processes and target identification.
• Catalyst Ligand Development: The quinoline structure can be modified to create novel ligands for transition metal catalysts used in cross-coupling and other organic transformations.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up services for clients requiring specific, complex quinoline derivatives.

Basic Information

Item	Detail
Product Name	8-Chloro-2-(2-Methylphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160263-55-7
Molecular Formula	C18H11Cl2NO
Molecular Weight	328.19 g/mol
Synonyms	8-Chloro-2-(o-tolyl)quinoline-4-carbonyl chloride; 2-(2-Methylphenyl)-8-chloroquinoline-4-carbonyl chloride; 4-Chlorocarbonyl-8-chloro-2-(2-methylphenyl)quinoline; 1160263-55-7; Quinoline-4-carbonyl chloride, 8-chloro-2-(2-methylphenyl)-; 8-Chloro-2-(2-methylphenyl)-4-quinolinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-(2-Methylphenyl)Quinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates for GMP or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.