Description

8-Chloro-2-(4-Methylphenyl)Quinoline-4-Carbonyl Chloride is a high-value, multi-functional organic intermediate with significant synthetic utility. Its core value lies in its dual reactive sites—the acid chloride and the chloro-substituted quinoline ring—which enable its use as a versatile building block for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, anti-cancer agents, and other biologically active heterocyclic compounds.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, leveraging the quinoline scaffold for bioactivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialty polymers, organic semiconductors, and luminescent materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes.
• Catalyst Ligand Precursor: The functional groups can be modified to create novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	8-Chloro-2-(4-Methylphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160263-51-3
Molecular Formula	C18H11Cl2NO
Molecular Weight	328.19 g/mol
Synonyms	8-Chloro-2-p-tolylquinoline-4-carbonyl chloride; 2-(4-Methylphenyl)-8-chloroquinoline-4-carbonyl chloride; 4-Chlorocarbonyl-8-chloro-2-(4-methylphenyl)quinoline; 8-Chloro-2-(4-methylphenyl)-4-quinolinecarbonyl chloride; Quinoline-4-carbonyl chloride, 8-chloro-2-(4-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-(4-Methylphenyl)Quinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.