Description

2-(4-Butoxyphenyl)-6-Chloroquinoline-4-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride functional group. This compound matters for its critical role as a key building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

This specialized intermediate is designed for sophisticated synthetic applications, particularly in regulated industries.

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially those with quinoline-based structures.
• Organic Synthesis Building Block: Used in amide bond formation and other coupling reactions to construct complex molecular architectures for research and development.
• Agrochemical Research: Employed in the development of new active ingredients for crop protection products, leveraging its halogenated quinoline core.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and functional handles.
• Chemical Biology Probe Development: Utilized to create tagged or modified molecules for studying biological pathways and target engagement.

Basic Information

Product Name	2-(4-Butoxyphenyl)-6-Chloroquinoline-4-Carbonyl Chloride
CAS No.	1160263-40-0
Molecular Formula	C21H19Cl2NO2
Molecular Weight	388.29 g/mol
Synonyms	6-Chloro-2-[4-(butoxy)phenyl]quinoline-4-carbonyl chloride; 2-(4-Butoxyphenyl)-6-chloro-4-quinolinecarbonyl chloride; 6-Chloro-2-(4-butoxyphenyl)quinoline-4-carbonyl chloride; 4-Quinolinecarbonyl chloride, 6-chloro-2-[4-(butoxy)phenyl]-; 2-(p-Butoxyphenyl)-6-chloroquinoline-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-(4-Butoxyphenyl)-6-Chloroquinoline-4-Carbonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic workflows. All materials undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in GMP-oriented applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.